Publication list scientific project RHU PERTINENCE

1          Matta J, Carette C, Rives Lange C, Czernichow S. [French and worldwide epidemiology of obesity]. Presse Med. 2018; 47: 434-38.

2          https://www.roche.fr/fr/innovation-recherche-medicale/decouverte-scientifique-medicale/cardio-metabolisme/enquete-nationale-obepi-2012.html. 2012.

3          Peirson L, Douketis J, Ciliska D, Fitzpatrick-Lewis D, Ali MU, Raina P. Treatment for overweight and obesity in adult populations: a systematic review and meta-analysis. CMAJ Open. 2014; 2: E306-17.

4          Peirson L, Fitzpatrick-Lewis D, Morrison K, Warren R, Usman Ali M, Raina P. Treatment of overweight and obesity in children and youth: a systematic review and meta-analysis. CMAJ Open. 2015; 3: E35-46.

5          Withrow D, Alter DA. The economic burden of obesity worldwide: a systematic review of the direct costs of obesity. Obesity reviews : an official journal of the International Association for the Study of Obesity. 2011; 12: 131-41.

6          Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128.9 million children, adolescents, and adults. Lancet. 2017; 390: 2627-42.

7          Reddon H, Gueant JL, Meyre D. The importance of gene-environment interactions in human obesity. Clin Sci (Lond). 2016; 130: 1571-97.

8          Chatelan A, Bochud M, Frohlich KL. Precision nutrition: hype or hope for public health interventions to reduce obesity? International journal of epidemiology. 2019; 48: 332-42.

9          Guh DP, Zhang W, Bansback N, Amarsi Z, Birmingham CL, Anis AH. The incidence of co-morbidities related to obesity and overweight: a systematic review and meta-analysis. BMC public health. 2009; 9: 88.

10        Fontaine KR, Barofsky I. Obesity and health-related quality of life. Obesity reviews : an official journal of the International Association for the Study of Obesity. 2001; 2: 173-82.

11        Fontaine KR, Redden DT, Wang C, Westfall AO, Allison DB. Years of life lost due to obesity. Jama. 2003; 289: 187-93.

12        Friedman KE, Reichmann SK, Costanzo PR, Zelli A, Ashmore JA, Musante GJ. Weight stigmatization and ideological beliefs: relation to psychological functioning in obese adults. Obes Res. 2005; 13: 907-16.

13        Fernandez-Twinn DS, Hjort L, Novakovic B, Ozanne SE, Saffery R. Intrauterine programming of obesity and type 2 diabetes. Diabetologia. 2019; 62: 1789-801.

14        Li C, Lumey LH. Exposure to the Chinese famine of 1959-61 in early life and long-term health conditions: a systematic review and meta-analysis. International journal of epidemiology. 2017; 46: 1157-70.

15        Kensara OA, Wootton SA, Phillips DI, Patel M, Jackson AA, Elia M. Fetal programming of body composition: relation between birth weight and body composition measured with dual-energy X-ray absorptiometry and anthropometric methods in older Englishmen. The American journal of clinical nutrition. 2005; 82: 980-7.

16        Harder T, Rodekamp E, Schellong K, Dudenhausen JW, Plagemann A. Birth weight and subsequent risk of type 2 diabetes: a meta-analysis. American journal of epidemiology. 2007; 165: 849-57.

17        Frias AE, Grove KL. Obesity: a transgenerational problem linked to nutrition during pregnancy. Seminars in reproductive medicine. 2012; 30: 472-8.

18        Veenendaal MV, Painter RC, de Rooij SR, Bossuyt PM, van der Post JA, Gluckman PD, et al. Transgenerational effects of prenatal exposure to the 1944-45 Dutch famine. BJOG : an international journal of obstetrics and gynaecology. 2013; 120: 548-53.

19        Li A, Teo KK, Morrison KM, McDonald SD, Atkinson SA, Anand SS, et al. A genetic link between prepregnancy body mass index, postpartum weight retention, and offspring weight in early childhood. Obesity (Silver Spring). 2017; 25: 236-43.

20        Li A, Robiou-du-Pont S, Anand SS, Morrison KM, McDonald SD, Atkinson SA, et al. Parental and child genetic contributions to obesity traits in early life based on 83 loci validated in adults: the FAMILY study. Pediatric obesity. 2018; 13: 133-40.

21        Stryjecki C, Alyass A, Meyre D. Ethnic and population differences in the genetic predisposition to human obesity. Obesity reviews : an official journal of the International Association for the Study of Obesity. 2018; 19: 62-80.

22        Yang J, Bakshi A, Zhu Z, Hemani G, Vinkhuyzen AA, Lee SH, et al. Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index. Nature genetics. 2015; 47: 1114-20.

23        Kaur Y, de Souza RJ, Gibson WT, Meyre D. A systematic review of genetic syndromes with obesity. Obesity reviews : an official journal of the International Association for the Study of Obesity. 2017; 18: 603-34.

24        Lunsky IO, Meyre D. Decoding Mendelian obesity. Curr Opin Endocr Metab Res. 2019; 4: 21-28.

25        Tam V, Turcotte M, Meyre D. Established and emerging strategies to crack the genetic code of obesity. Obesity reviews : an official journal of the International Association for the Study of Obesity. 2019; 20: 212-40.

26        Walters RG, Jacquemont S, Valsesia A, de Smith AJ, Martinet D, Andersson J, et al. A new highly penetrant form of obesity due to deletions on chromosome 16p11.2. Nature. 2010; 463: 671-5.

27        Bonnefond A, Raimondo A, Stutzmann F, Ghoussaini M, Ramachandrappa S, Bersten DC, et al. Loss-of-function mutations in SIM1 contribute to obesity and Prader-Willi-like features. The Journal of clinical investigation. 2013; 123: 3037-41.

28        Chen S, Meyre D. An update on Mendelian forms of obesity and their personalized treatments. Obesity and Diabetes Scientific Advances and Best Practice Second Edition Springer. 2020: 207-12.

29        Saeed S, Arslan M, Manzoor J, Din SM, Janjua QM, Ayesha H, et al. Genetic Causes of Severe Childhood Obesity: A Remarkably High Prevalence in an Inbred Population of Pakistan. Diabetes. 2020; 69: 1424-38.

30        Nordang GBN, Busk OL, Tveten K, Hanevik HI, Fell AKM, Hjelmesaeth J, et al. Next-generation sequencing of the monogenic obesity genes LEP, LEPR, MC4R, PCSK1 and POMC in a Norwegian cohort of patients with morbid obesity and normal weight controls. Molecular genetics and metabolism. 2017; 121: 51-56.

31        Kleinendorst L, Massink MPG, Cooiman MI, Savas M, van der Baan-Slootweg OH, Roelants RJ, et al. Genetic obesity: next-generation sequencing results of 1230 patients with obesity. J Med Genet. 2018; 55: 578-86.

32        Altshuler D, Daly MJ, Lander ES. Genetic mapping in human disease. Science. 2008; 322: 881-8.

33        Yengo L, Sidorenko J, Kemper KE, Zheng Z, Wood AR, Weedon MN, et al. Meta-analysis of genome-wide association studies for height and body mass index in approximately 700000 individuals of European ancestry. Human molecular genetics. 2018.

34        Dina C, Meyre D, Gallina S, Durand E, Korner A, Jacobson P, et al. Variation in FTO contributes to childhood obesity and severe adult obesity. Nature genetics. 2007; 39: 724-6.

35        Loos RJ, Lindgren CM, Li S, Wheeler E, Zhao JH, Prokopenko I, et al. Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nature genetics. 2008; 40: 768-75.

36        Benzinou M, Creemers JW, Choquet H, Lobbens S, Dina C, Durand E, et al. Common nonsynonymous variants in PCSK1 confer risk of obesity. Nature genetics. 2008; 40: 943-5.

37        Meyre D, Delplanque J, Chevre JC, Lecoeur C, Lobbens S, Gallina S, et al. Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations. Nature genetics. 2009; 41: 157-9.

38        Paternoster L, Evans DM, Nohr EA, Holst C, Gaborieau V, Brennan P, et al. Genome-wide population-based association study of extremely overweight young adults–the GOYA study. PloS one. 2011; 6: e24303.

39        Jiao H, Arner P, Hoffstedt J, Brodin D, Dubern B, Czernichow S, et al. Genome wide association study identifies KCNMA1 contributing to human obesity. BMC medical genomics. 2011; 4: 51.

40        Berndt SI, Gustafsson S, Magi R, Ganna A, Wheeler E, Feitosa MF, et al. Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nature genetics. 2013; 45: 501-12.

41        Khera AV, Chaffin M, Aragam KG, Haas ME, Roselli C, Choi SH, et al. Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations. Nature genetics. 2018; 50: 1219-24.

42        Khera AV, Chaffin M, Wade KH, Zahid S, Brancale J, Xia R, et al. Polygenic Prediction of Weight and Obesity Trajectories from Birth to Adulthood. Cell. 2019; 177: 587-96 e9.

43        Chami N, Preuss M, Walker RW, Moscati A, Loos RJF. The role of polygenic susceptibility to obesity among carriers of pathogenic mutations in MC4R in the UK Biobank population. PLoS medicine. 2020; 17: e1003196.

44        Wahart A, Hocine T, Albrecht C, Henry A, Sarazin T, Martiny L, et al. Role of elastin peptides and elastin receptor complex in metabolic and cardiovascular diseases. The FEBS journal. 2019; 286: 2980-93.

45        Talukdar S, Oh DY, Bandyopadhyay G, Li D, Xu J, McNelis J, et al. Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase. Nature medicine. 2012; 18: 1407-12.

46        Mansuy-Aubert V, Zhou QL, Xie X, Gong Z, Huang JY, Khan AR, et al. Imbalance between neutrophil elastase and its inhibitor alpha1-antitrypsin in obesity alters insulin sensitivity, inflammation, and energy expenditure. Cell metabolism. 2013; 17: 534-48.

47        Lafarge JC, Pini M, Pelloux V, Orasanu G, Hartmann G, Venteclef N, et al. Cathepsin S inhibition lowers blood glucose levels in mice. Diabetologia. 2014; 57: 1674-83.

48        Bell CG, Finer S, Lindgren CM, Wilson GA, Rakyan VK, Teschendorff AE, et al. Integrated genetic and epigenetic analysis identifies haplotype-specific methylation in the FTO type 2 diabetes and obesity susceptibility locus. PloS one. 2010; 5: e14040.

49        Oussalah A, Rischer S, Bensenane M, Conroy G, Filhine-Tresarrieu P, Debard R, et al. Plasma mSEPT9: A Novel Circulating Cell-free DNA-Based Epigenetic Biomarker to Diagnose Hepatocellular Carcinoma. EBioMedicine. 2018; 30: 138-47.

50        Gueant JL, Namour F, Gueant-Rodriguez RM, Daval JL. Folate and fetal programming: a play in epigenomics? Trends in endocrinology and metabolism: TEM. 2013; 24: 279-89.

51        Dali-Youcef N, Vix M, Costantino F, El-Saghire H, Lhermitte B, Callari C, et al. Interleukin-32 Contributes to Human Nonalcoholic Fatty Liver Disease and Insulin Resistance. Hepatology communications. 2019; 3: 1205-20.

52        Gueant JL, Chery C, Oussalah A, Nadaf J, Coelho D, Josse T, et al. APRDX1 mutant allele causes a MMACHC secondary epimutation in cblC patients. Nature communications. 2018; 9: 67.

53        Levy J, Rodriguez-Gueant RM, Oussalah A, Jeannesson E, Wahl D, Ziuly S, et al. Cardiovascular manifestations of intermediate and major hyperhomocysteinemia due to vitamin B12 and folate deficiency and/or inherited disorders of one-carbon metabolism: a 3.5-year retrospective cross-sectional study of consecutive patients. The American journal of clinical nutrition. 2021; 113: 1157-67.

54        Li Z, Gueant-Rodriguez RM, Quilliot D, Sirveaux MA, Meyre D, Gueant JL, et al. Folate and vitamin B12 status is associated with insulin resistance and metabolic syndrome in morbid obesity. Clin Nutr. 2018; 37: 1700-06.

55        Antoine D, Guéant-Rodriguez RM, Chèvre JC, Hergalant S, Sharma T, Li Z, et al. Rare coding variants associated with body-mass-index impact outcomes of bariatric surgery in patients with morbid obesity. The Journal of clinical endocrinology and metabolism. 2021; in revision.

56        Balbinot C, Armant O, Elarouci N, Marisa L, Martin E, De Clara E, et al. The Cdx2 homeobox gene suppresses intestinal tumorigenesis through non-cell-autonomous mechanisms. The Journal of experimental medicine. 2018; 215: 911-26.

57        Beck M, Baranger M, Moufok-Sadoun A, Bersuder E, Hinkel I, Mellitzer G, et al. The atypical cadherin MUCDHL antagonizes colon cancer formation and inhibits oncogenic signaling through multiple mechanisms. Oncogene. 2021; 40: 522-35.

58        Godart M, Frau C, Farhat D, Giolito MV, Jamard C, Le Neve C, et al. Murine intestinal stem cells are highly sensitive to modulation of the T3/TRalpha1-dependent pathway. Development. 2021; 148.

59        Frau C, Jamard C, Delpouve G, Guardia GDA, Machon C, Pilati C, et al. Deciphering the Role of Intestinal Crypt Cell Populations in Resistance to Chemotherapy. Cancer research. 2021; 81: 2730-44.

60        Toti E, Di Mattia C, Serafini M. Corrigendum: Metabolic Food Waste and Ecological Impact of Obesity in FAO World’s Region. Frontiers in nutrition. 2019; 6: 160.

61        Kudel I, Huang JC, Ganguly R. Impact of Obesity on Work Productivity in Different US Occupations: Analysis of the National Health and Wellness Survey 2014 to 2015. Journal of occupational and environmental medicine. 2018; 60: 6-11.

62        Morassut RE, Langlois C, Alyass A, Ishola AF, Yazdi FT, Mayhew AJ, et al. Rationale and design of GENEiUS: a prospective observational study on the genetic and environmental determinants of body mass index evolution in Canadian undergraduate students. BMJ open. 2017; 7: e019365.

63        Sharma T, Langlois C, Morassut RE, Meyre D. Effect of living arrangement on anthropometric traits in first-year university students from Canada: The GENEiUS study. PloS one. 2020; 15: e0241744.

64        Sharma T, Manoharan B, Langlois C, Morassut RE, Meyre D. The effect of race/ethnicity on obesity traits in first year university students from Canada: The GENEiUS study. PloS one. 2020; 15: e0242714.

65        Sharma T, Morassut RE, Langlois C, Meyre D. Effect of sex/gender on obesity traits in Canadian first year university students: The GENEiUS study. PloS one. 2021; 16: e0247113.

66        Curtis D. Weighted burden analysis in 200 000 exome-sequenced UK Biobank subjects characterises effects of rare genetic variants on BMI. MedrXiv. 2021.

67        Yazdi FT, Clee SM, Meyre D. Obesity genetics in mouse and human: back and forth, and back again. PeerJ. 2015; 3: e856.

68        Wang DX, Kaur Y, Alyass A, Meyre D. A Candidate-Gene Approach Identifies Novel Associations Between Common Variants in/Near Syndromic Obesity Genes and BMI in Pediatric and Adult European Populations. Diabetes. 2019; 68: 724-32.

69        Yengo L, Sidorenko J, Kemper KE, Zheng Z, Wood AR, Weedon MN, et al. Meta-analysis of genome-wide association studies for height and body mass index in approximately 700000 individuals of European ancestry. Human molecular genetics. 2018; 27: 3641-49.

70        Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, et al. Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Nature genetics. 2018; 50: 26-41.

71        O’Rahilly S, Farooqi IS. Human obesity as a heritable disorder of the central control of energy balance. Int J Obes (Lond). 2008; 32 Suppl 7: S55-61.

72        Ochoa D, Hercules A, Carmona M, Suveges D, Gonzalez-Uriarte A, Malangone C, et al. Open Targets Platform: supporting systematic drug-target identification and prioritisation. Nucleic acids research. 2021; 49: D1302-D10.

73        Ghoussaini M, Mountjoy E, Carmona M, Peat G, Schmidt EM, Hercules A, et al. Open Targets Genetics: systematic identification of trait-associated genes using large-scale genetics and functional genomics. Nucleic acids research. 2021; 49: D1311-D20.

74        Liu R, Zou Y, Hong J, Cao M, Cui B, Zhang H, et al. Rare Loss-of-Function Variants in NPC1 Predispose to Human Obesity. Diabetes. 2017; 66: 935-47.

75        Pearce LR, Atanassova N, Banton MC, Bottomley B, van der Klaauw AA, Revelli JP, et al. KSR2 mutations are associated with obesity, insulin resistance, and impaired cellular fuel oxidation. Cell. 2013; 155: 765-77.

76        Yang Y, van der Klaauw AA, Zhu L, Cacciottolo TM, He Y, Stadler LKJ, et al. Steroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis. Nature communications. 2019; 10: 1718.

77        Marenne G, Hendricks AE, Perdikari A, Bounds R, Payne F, Keogh JM, et al. Exome Sequencing Identifies Genes and Gene Sets Contributing to Severe Childhood Obesity, Linking PHIP Variants to Repressed POMC Transcription. Cell metabolism. 2020; 31: 1107-19 e12.

78        Keramati AR, Fathzadeh M, Go GW, Singh R, Choi M, Faramarzi S, et al. A form of the metabolic syndrome associated with mutations in DYRK1B. The New England journal of medicine. 2014; 370: 1909-19.

79        Croft JB, Morrell D, Chase CL, Swift M. Obesity in heterozygous carriers of the gene for the Bardet-Biedl syndrome. American journal of medical genetics. 1995; 55: 12-5.

80        Ichimura A, Hirasawa A, Poulain-Godefroy O, Bonnefond A, Hara T, Yengo L, et al. Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human. Nature. 2012; 483: 350-4.

81        Doche ME, Bochukova EG, Su HW, Pearce LR, Keogh JM, Henning E, et al. Human SH2B1 mutations are associated with maladaptive behaviors and obesity. The Journal of clinical investigation. 2012; 122: 4732-6.

82        Kaiser J. The hunt for missing genes. Science. 2014; 344: 687-9.

83        Kebede MA, Attie AD. Insights into obesity and diabetes at the intersection of mouse and human genetics. Trends in endocrinology and metabolism: TEM. 2014; 25: 493-501.

84        Vazquez-Moreno M, Zeng H, Locia-Morales D, Peralta-Romero J, Asif H, Maharaj A, et al. The Melanocortin 4 Receptor p.Ile269Asn Mutation Is Associated with Childhood and Adult Obesity in Mexicans. The Journal of clinical endocrinology and metabolism. 2020; 105.

85        Vazquez-Moreno M, Locia-Morales D, Valladares-Salgado A, Sharma T, Wacher-Rodarte N, Cruz M, et al. Sex/Gender Modifies the Association Between the MC4R p.Ile269Asn Mutation and Type 2 Diabetes in the Mexican Population. The Journal of clinical endocrinology and metabolism. 2021; 106: e112-e17.

86        Vazquez-Moreno M, Locia-Morales D, Valladares-Salgado A, Sharma T, Perez-Herrera A, Gonzalez-Dzib R, et al. The MC4R p.Ile269Asn mutation confers a high risk for type 2 diabetes in the Mexican population via obesity dependent and independent effects. Scientific reports. 2021; 11: 3097.

87        Chiorean A, Garver WS, Meyre D. Signatures of natural selection and ethnic-specific prevalence of NPC1 pathogenic mutations contributing to obesity and Niemann-Pick disease type C1. Scientific reports. 2020; 10: 18787.

88        Richards S, Aziz N, Bale S, Bick D, Das S, Gastier-Foster J, et al. Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology. Genetics in medicine : official journal of the American College of Medical Genetics. 2015; 17: 405-24.

89        Ehtesham S, Qasim A, Meyre D. Loss-of-function mutations in the melanocortin-3 receptor gene confer risk for human obesity: A systematic review and meta-analysis. Obesity reviews : an official journal of the International Association for the Study of Obesity. 2019; 20: 1085-92.

90        Majithia AR, Tsuda B, Agostini M, Gnanapradeepan K, Rice R, Peloso G, et al. Prospective functional classification of all possible missense variants in PPARG. Nature genetics. 2016; 48: 1570-75.

91        Castillo JJ, Jelinek D, Wei H, Gannon NP, Vaughan RA, Horwood LJ, et al. The Niemann-Pick C1 gene interacts with a high-fat diet to promote weight gain through differential regulation of central energy metabolism pathways. American journal of physiology Endocrinology and metabolism. 2017: ajpendo 00369 2016.

92        Lamri A, Pigeyre M, Garver WS, Meyre D. The extending spectrum of NPC1-related human disorders: from Niemann-Pick C1 Disease to obesity. Endocrine reviews. 2018.

93        Qasim A, Turcotte M, de Souza RJ, Samaan MC, Champredon D, Dushoff J, et al. On the origin of obesity: identifying the biological, environmental and cultural drivers of genetic risk among human populations. Obesity reviews : an official journal of the International Association for the Study of Obesity. 2018; 19: 121-49.

94        Kaur Y, Wang DX, Liu HY, Meyre D. Comprehensive identification of pleiotropic loci for body fat distribution using the NHGRI-EBI Catalog of published genome-wide association studies. Obesity reviews : an official journal of the International Association for the Study of Obesity. 2019; 20: 385-406.

95        Zachurzok A, Ranke MB, Flehmig B, Jakubek-Kipa K, Marcinkiewicz K, Mazur A, et al. Relative leptin deficiency in children with severe early-onset obesity (SEOO) – results of the Early-onset Obesity and Leptin – German-Polish Study (EOL-GPS). Journal of pediatric endocrinology & metabolism : JPEM. 2020; 33: 255-63.