Biomarkers, predictors and stratified medicine (PI JY Jouzeau)

Rationale

Biomarkers are tools used to prevent, stratify and predict disease and to improve the quality of care and quality of life of patients. The complexity of chronic diseases related to ageing, their slow evolution and their multifactorial origin make the identification of biomarkers a difficult task.

This WP aim to produce new biomarkers and to design panels according to BIPED classification:
(i) progression of disease, burden of disease
(ii) efficacy
(iii) identification of patients and subgroups
(iv) prognostic
(v) Investigatory.

General strategy

We will validate biomarkers profiles and panels in clinically well-defined cohorts and search for new ones to improve the diagnosis, prognosis and therapeutic management of the three groups of diseases. Signatures will be obtained in cohorts of patients with or without co-morbidities (for example OA w or w/o obesity or IBD w or w/o joint inflammation).

The combined use of biomarkers will enable the stratification of patients and identification of those “at the corner” between diseases, therefore improving their isolation in particular phenotype subsets (figure).