Sylviane Muller

S. Muller is interested in understanding the molecular and cellular pathways involved in autoreactive lymphocytes activation, the events leading to cell death/living phenomena that are central in auto-inflammatory diseases (e.g. Lupus), and in the fundamental mechanisms of therapeutic responses. Combining her fundamental knowledge of lupus with a long-lasting experience in peptide immunochemistry, S. Muller and her team were able to develop a very novel strategy, based on synthetic peptides, designed to modulate the aberrant immune response and restore immune system functions in model mice and patients with lupus. One of these peptides is currently evaluated worldwide in advanced clinical trials. This peptide that act via autophagy showed bio-clinical activity in animal models mimicking other chronic inflammatory diseases (e.g., Sjögren’s syndrome, CIDP, asthma, IBD). Current studies are developed in metabolic diseases (diabetes, diabetic kidney disease, obesity).

Laurent Duca

Professor at the University of Reims Champagne-Ardenne where he leads with Dr. Stéphane Jaisson a team dealing with Matrix Aging and Vascular Remodeling (UMR CNRS/URCA 7369 MEDyC), Laurent Duca is interested in the mechanisms leading to vascular elastolysis and in the role played by elastin-derived peptides (EDP) in the development of vascular and metabolic diseases.

Pascal Villa

The PCBIS laboratory (UAR 3286 : Platform of Integrative Chemistry and Biology of Strasbourg :www.pcbis.fr), aims at giving access to assay development, screening facilities, early ADMETox services and to a collection of small molecules to academic laboratories and to small companies in order to develop either research tools or starting points for drug candidates.
PCBIS is ISO 9001 certified since 2007 NF X50-900 certified since 2014. PCBIS is labelled IBiSA, belongs to the National infrastructure ChemBioFrance and is part of the Institut du Médicament de Strasbourg.

Philippe Gillery

Prof. Philippe Gillery, MD, PhD, is Professor of Biochemistry and Molecular Biology at the Faculty of Medicine of Reims, University of Reims Champagne-Ardenne, France. He is the Chair of the Laboratory of Biochemistry-Pharmacology-Toxicology and of the Biology and Pathology Department of the University Hospital of Reims, France, and deputy Director of CNRS Unit « Extracellular Matrix and Cell Dynamics ».
He is currently appointed as Chair of the Scientific Division of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC), and is Associate Editor of the Clinical Chemistry and Laboratory Medicine Journal. His research interests are related to the effects of nonenzymatic post-translational modifications (especially glycation and carbamylation) on protein structure and functions, and to their involvement in the pathophysiology of diabetes mellitus and other chronic diseases. He has published more than 240 articles in peer-reviewed journals.

Sébastien Blaise

Dr Sébastien Blaise, assistant professor at Reims Champagne-Ardenne University and in team 2 of CNRS Unit « Extracellular Matrix and Cell Dynamics ». His main works concern the interplay between extracellular matrix remodeling  and metabolism syndrome progression.

Emmanuel Andrès

In 2002, E. Andrès was nominated Professor at the University of Strasbourg, France. He also was nominated at the head of an Internal Medicine Department in the University hospital of Strasbourg, France. Achievements include development of research in: all type of anaemia, neutropenia and thrombocytopenia; haematopoietic growth factors; and cobalamin deficiencies. He also conducts several studies on inflammatory or immune disorders. His recent works also include research and development on human sounds analysis, electronic stethoscope, e-auscultation, and e-medicine. His recent works also include research and development on telemedicine, particularly for chronic disorders as chronic heart failure and diabetes mellitus.

Didier Quilliot

Didier Quilliot, Professor of Nutrition. My research activities are related to my clinical skills, which are essentially clinical nutrition, artificial nutrition (long-term parenteral nutrition, short bowel syndrome, post-digestive surgery), nutrition and IBD, undernutrition (cancer, chronic diseases) and eating disorders (BED, anorexia). I also take care of obesity surgery, course coordination, management of nutritional and functional complications (cohort of 3000 patients after gastric bypass).